MAROKO133 Hot ai: Alzheimer’s Fully Reversed in Mice, Scientists Say Edisi Jam 15:18

📌 MAROKO133 Breaking ai: Alzheimer’s Fully Reversed in Mice, Scientists Say Edisi

A team of American scientists claim they have done something miraculous: they “cured” lab mice suffering from Alzheimer’s disease, which has robbed more than seven million Americans, typically 65 years old and up, of their identity and cognitive ability.

The researchers achieved this feat by administering the rodents with the powerful compound P7C3-A20, which they announced in a new paper in the journal Cell Reports Medicine. Scientists from Ohio’s Case Western Reserve University (CWRU), University Hospitals, and the Louis Stokes Cleveland VA Medical Center undertook the study.

“The key takeaway is a message of hope — the effects of Alzheimer’s disease may not be inevitably permanent,” said Andrew A. Pieper, the study’s principal investigator and a CWRU neuroscience professor, in a statement about the research. “The damaged brain can, under some conditions, repair itself and regain function.”

This research is part of a growing wave of very promising lab studies that point to a tantalizing future where Alzheimer’s and other neurological issues could be a thing of the past. Besides this P7C3-A20 research, others have scored remarkable lab results using different compounds and treatments.

This has made normally cautious scientists so excited that they are making bold predictions. University of Edinburgh neuroscience professor Tara Spires-Jones, who wasn’t part of this P7C3-A20 study, told the BBC this month she thinks scientists are closer than ever to a “truly life-changing” treatment — in as little as five to 10 years; instead of a slow death where people lose themselves, she forecasts that new tests will detect the condition early and innovative treatments will “really make your life normal.”

Scientists are also closer to understanding what causes Alzheimer’s, which seems to be sparked by different factors such as genetics, environment and other stressors — which means that future patients may receive personalized cocktail of anti-Alzheimer’s treatment and drugs suited for their own situation.

Regardless of the cause, previous research has suggested that Alzheimer’s is a form of inflammation. That means lessening or zeroing out inflammation in the brain would be key rather than managing symptoms.

In the P7C3-A20 study, the scientists focused on the impact of the crucial molecule NAD+, a coenzyme important for driving cellular metabolism and which decreases as we age, according to the study. Patients with Alzheimer’s suffer from a significant decrease of NAD+ in the brain, and hence their brain cells have trouble maintaining normal functionality, staving off inflammation, and canceling other physical hallmarks of the disease.

For the study, the team first took two types of lab mice that have been genetically bred to be predisposed to Alzheimer’s; one cohort had mutations for the amyloid protein and the other had tau protein mutations. Both proteins are important to cellular function, but they can become dangerous if they accrete in the brain in the form of amyloid plaques and tau tangles — causing a breakdown in normal cellular processes.

The team injected P7C3-A20 into both mice cohorts at two months of age, later finding out that this treatment successfully prevented them from developing the disease. But the big news was when they injected the compound into another batch of lab mice, who were suffering from a relatively advanced stage of Alzheimer’s at six months of age; after getting injections, these mice completely recovered their cognitive ability and NAD+ levels were restored to homeostasis leve;s

“We were very excited and encouraged by our results,” said Pieper in the statement. “Restoring the brain’s energy balance achieved pathological and functional recovery in both lines of mice with advanced Alzheimer’s. Seeing this effect in two very different animal models, each driven by different genetic causes, strengthens the new idea that recovery from advanced disease might be possible in people with AD when the brain’s NAD+ balance is restored.”

What’s also good about this study is that P7C3-A20 offers an alternative pathway to boosting NAD+ levels versus taking over-the-counter chemical precursors for NAD+, which can can raise NAD+ to such toxic levels that people could develop cancer, Pieper said. Supplements to boost NAD+ are just a click away on your cellphone, which should be worrying for anybody concerned about cancer.

The team wants to move to human clinical trials but some people are clearly not waiting; if you search online on how to obtain P7C3-A20 for yourself, numerous websites selling vials of the compound will pop up.

More on Alzheimer’s disease: Scientists Identify Possible Game Changing Treatment for Alzheimer’s Disease That Could Control It Like High Cholesterol

The post Alzheimer’s Fully Reversed in Mice, Scientists Say appeared first on Futurism.

🔗 Sumber: futurism.com

📌 MAROKO133 Hot ai: World’s first 6-ton tiltrotor aircraft with 342 mph top speed

A Chinese-built tiltrotor aircraft weighing about six tons reached a major aviation milestone on Sunday when it completed its maiden flight in Southwest China’s Sichuan Province.

The tiltrotor aircraft, called the Lanying R6000, is the world’s first tiltrotor in its weight class and was independently developed by United Aircraft, marking a notable step in China’s push into advanced vertical lift aviation.

Designed to combine helicopter-like flexibility with airplane-level speed and range, the R6000 aims to reshape regional air travel. Its first flight signals more than a test success. It highlights China’s growing ambitions in tiltrotor technology, a field long dominated by a handful of global players.

A new chapter for tiltrotor aircrafts in aviation

According to United Aircraft, the R6000 tiltrotor aircraft is intended for point-to-point air commuting in cities, across sea routes, and in mountainous regions. The company said the aircraft can shorten travel times and reduce geographic barriers while helping to build cross-regional “door-to-door transport networks, according to a release sent to the Global Times by United Aircraft.”

Project manager Zhao Fengming described the achievement as a breakthrough moment for the country’s aerospace sector. “The emergence of the R6000 indicates that China has reached the forefront of the world in the cutting-edge aviation field of tiltrotor, breaking the long-standing technological monopoly,” said Zhao, as reported by Global Times.

Powering the aircraft is the AES100 engine, developed independently by the Aero Engine Corporation of China.

Engineering choices that set it apart

The Lanying R6000 uses a distinctive tiltrotor configuration that allows it to smoothly transition between vertical takeoff and landing and high-speed horizontal flight. This approach blends the precise hovering and vertical lift of helicopters with the longer range and faster cruise of fixed-wing aircraft.

Unlike designs that rotate entire engine nacelles, the R6000 uses a tilting-rotor shaft system. United Aircraft says this choice reduces complexity and delivers advances in both flight control and power system design. It also prevents ground crews and nearby structures from being exposed to hot exhaust airflow during takeoff and landing.

This feature is especially important for maritime operations. By reducing heat-related risks, the aircraft can operate from ordinary ship decks and offshore platforms that lack specialized heat-resistant coatings, expanding its potential use at sea.

Speed, range, and smart storage

In fixed-wing mode, the R6000 cruises at about 342 miles per hour, roughly twice the speed of traditional helicopters. It can carry a maximum commercial payload of about 4,409 pounds, which is significantly higher than that of similarly sized helicopters.

The aircraft’s maximum range reaches roughly 2,485 miles, around four times that of conventional helicopters, with a service ceiling near 25,000 feet. These figures position the R6000 for long-distance missions that typically fall outside the reach of rotary-wing aircraft.

To address space constraints, the design includes tandem-wing folding and blade-retraction technologies. These features reduce the aircraft’s footprint when parked, making storage and deployment easier in confined areas such as urban pads and ship decks.

Roles in a growing low-altitude economy

The company said the successful maiden flight reflects breakthroughs in core tiltrotor technologies, including an intelligent tilt-and-flight control system with fully independent intellectual property rights. The transmission system meets strict aviation safety standards, supporting future large-scale use.

Beyond commuter travel, the R6000 is expected to support medical evacuations, firefighting, police patrols, and disaster relief, where rapid and precise deployment is critical. The company also sees opportunities in high-end private travel and aerial sightseeing.

These ambitions align with China’s broader low-altitude economy. Xinhua News Agency has reported growing use of drones and helicopters for deliveries and tourism.

Forecasts from the Civil Aviation Administration of China estimate the low-altitude market could reach about $210 billion by 2025 and potentially exceed $490 billion by 2035, highlighting the expanding space below 3,280 feet where new aircraft like the R6000 may soon operate.

🔗 Sumber: interestingengineering.com